|2. PRODUCT NAME & DETAILS|
|Product Name||Methyl 4-bromocrotonate|
|3. REGULATORY INFORMATION
||Common names and synonyms
|European Inventory of Existing Commercial Chemical Substances (EINECS)
|United States Toxic Substances Control Act (TSCA) Inventory
|China Catalog of Hazardous chemicals 2015
|Chinese Chemical Inventory of Existing Chemical Substances (China IECSC)
|Korea Existing Chemicals List (KECL)
|Canadian Domestic Substance List (DSL)
|Canadian Non-Domestic Substance List (NDSL)
|Japanese Existing and New Chemical Substances Inventory(ENCS)
||Pale Yellow To Orange Liquid
||Miscible With Methanol
|Moisture Content (KF)
|CIS Isomer (GC)
|5. APPLICATION||It is a useful synthetic intermediate.
It was used in the synthesis of irreversible inhibitors of EGFR and HER-2 tyrosine kinases with enhanced antitumor activities.
An antitumor drug Dacomitinib was synthesized using Methyl-4-bromocrotonate.
It is a inhibitor of EGFR (epidermal growth factor receptor).
|6. HAZARD CLASSIFICATION
||Hazardous substance. (UN No. 1760)
|7. ANNUAL CAPACITY||6 MT.
|8. STORAGE CONDITION
||Store in closed container at 25-30°C. Avoid direct sun light.
|9. PACKING DETAILS
||50kg GI Drum with Screw Lid.
|10. SHELF LIFE
|Typical properties should not be considered as specification.
Product covered by valid patents are not offered or supplied for commercial use. The Patent position should be verified by the customer.
Products will not be supplied to countries where they could be in conflict with existing patents.
Products currently covered by valid US patents are offered for R&D use in accordance with 35 USC 271 (e) (I) Above information is given in good faith and without warrenty.
The above information is given in good faith and is without warranty
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