6-Nitro-7-chloro-4-hydroxy quinazoline

1. STRUCTURE
6-Nitro-7-chloro-4-hydroxy quinazoline
2. PRODUCT NAME & DETAILS
Product Name 6-Nitro-7-chloro-4-hydroxy quinazoline
Product Code 002694
CAS No 53449-14-2
HS Code 2933.99.00
Molecular Formula C8H4CIN3O3
Molecular Wt. 225.590
3. REGULATORY INFORMATION
Chemical nameCommon names and synonymsCAS numberEC number
6-Nitro-7-chloro-4-hydroxy
quinazoline
7-Chloro-6-nitroquinazoline-4-ol
53449-14-2
678-360-9
European Inventory of Existing Commercial Chemical Substances (EINECS)
Not Listed
EC Inventory
Not Listed
United States Toxic Substances Control Act (TSCA) Inventory
Not Listed
China Catalog of Hazardous chemicals 2015
Not Listed
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC)
Not Listed
Korea Existing Chemicals List (KECL)
Not Listed
Canadian Domestic Substance List (DSL)
Not Listed
Canadian Non-Domestic Substance List (NDSL)
Not Listed
Japanese Existing and New Chemical Substances Inventory (ENCS)
Not Listed


4. SPECIFICATION
Physical AppearancePale Yellow Powder to Light Brown Powder
Melting Point
Min. 300.0 °C
Identification (HPLC)
RT of Sample Should Matches with Standard
Moisture Content (KF)
NMT 0.5%
7-Chloro-4[1h]-quinazolinone
MAX 0.5%
Any Others Impurity
MAX 0.1%
5,7-Dichloro-4[1h]quinazolinone
+7-chloro-8nitro-4[1h]quinazolin One
MAX 1.5%
Assay (HPLC)
NLT 98%
5. APPLICATIONIt is use as intermediate of Afatinib and Afatinib Dimaleate.
It is use in Anti-Cancer, Oncology Drug.
6. HAZARD CLASSIFICATION
             Acute Toxic                                    Irritant
7.ANNUAL CAPACITY 24 MT.
8. STORAGE CONDITION
Store in closed container at ambient temperature. Avoid direct sunlight.
9. PACKING DETAILS

Outer Packing : 25 kg HDPE UN Approved Open Mouth Drum 

Inner Packing : 2 plastic liner with  strip seal individually on each line

10. SHELF LIFE
1 year.
Disclaimer
Typical properties should not be considered as specification.
Product covered by valid patents are not offered or supplied for commercial use. The Patent position should be verified by the customer.
Products will not be supplied to countries where they could be in conflict with existing patents.
Products currently covered by valid US patents are offered for R&D use in accordance with 35 USC 271 (e) (I) Above information is given in good faith and without warrenty.

The above information is given in good faith and is without warranty