Tert-butyl Carbamate

Q1: What is Tert-butyl Carbamate and what antiviral drugs is it used to synthesize?

A1: Tert-butyl Carbamate (C5H11NO2, mol. wt. 117.15) is a white to off-white powder (melting point 108–110°C, assay NLT 99%) used as an intermediate in the synthesis of Nelfinavir and Saquinavir — two important antiretroviral drugs for HIV/AIDS treatment.

Q2: What important synthetic chemistry roles does Tert-butyl Carbamate play beyond antiviral APIs?

A2: It's used in palladium-catalyzed synthesis of N-Boc-protected anilines — a widely used method in pharmaceutical synthesis for introducing the Boc protecting group onto aromatic amines. It has also been used in synthesizing tetrasubstituted pyrroles with ester or ketone groups at the C-3 position.

Q3: What is the shelf life of Tert-butyl Carbamate compared to other pharma intermediates?

A3: It has a shelf life of 2 years — shorter than the typical 3 years of most Sarex pharmaceutical intermediates — and should be stored at ambient temperature in a closed container away from direct sunlight.

Q4: What is the annual manufacturing capacity and packaging for this product?

A4: Sarex produces it at 10 MT per year (one of its smaller-volume pharmaceutical intermediates) and packs it in either 15 kg corrugated boxes with PE liner or 300 kg big bags.

Q5: Can pharmaceutical companies source Tert-butyl Carbamate directly from Sarex as the manufacturer?

A5: Yes, Sarex is a leading fine chemical and pharmaceutical intermediate manufacturer in India and a major exporter, supplying Tert-butyl Carbamate directly to API and drug synthesis companies in more than 40 countries.