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Cyno acetic acid

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1. STRUCTURE
Cyno acetic acid
2. PRODUCT NAME & DETAILS
Product Name Cyno acetic acid
Product Code 003516
CAS No 372-09-8
HS Code 2926.90.00
Molecular Formula C3H3NO2
Molecular Wt. 85.06
3. REGULATORY INFORMATION
Chemical nameCommon names and synonymsCAS numberEC number
Cyanoacetic AcidCyanoacetic acid372-09-8206-743-9
European Inventory of Existing Commercial Chemical Substances (EINECS)Listed
EC InventoryListed
United States Toxic Substances Control Act (TSCA) InventoryListed
China Catalog of Hazardous chemicals 2015Not Listed
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC)Listed
Korea Existing Chemicals List (KECL)Listed
Canadian Domestic Substance List (DSL)Listed
Canadian Non-Domestic Substance List (NDSL)Not Listed
Japanese Existing and New Chemical Substances Inventory (ENCS)Listed


4. SPECIFICATION
Physical AppearanceA White To Slightly Yellowish Crystalline Hygroscopic Cr
Freezing Point64-68°C
Water Content (KF)NMT 1.0%
SolubilityClear Solution (5% In Water Is Clear)
Purity (HPLC)NLT 96%
5. APPLICATION- It is used as raw material to manufacture industrial organic chemicals.

- Cyanoacetic acid was used in the synthesis of N-piperidine-cyanacetamide and N-morpholyl-cyanacetamide. It was also used in the preparation of a panchromatic dye for dye-sensitized solar cells.

- Cyanoacetic acid can be used as a reagent:
  • Along with acetic anhydride for cyanoacetylation of various pyrroles, indoles, and aniline derivatives. It can also be used in other reactions such as cyclizations, syntheses of coumarins and other heterocycles.
  • To prepare of key intermediate via Knoevenagel condensation in the total synthesis of 5-acetamido-substituted melatonin derivatives as MT3 receptor ligands.
  • In the synthesis of aminopyrrolinone derivatives by reacting Ugi adducts of cyanoacetic acid and aromatic aldehydes.  
- The largest scale reaction is its esterification to give the corresponding ester ethyl cyanoacetate, which is then transformed to ethyl cyanoacrylate used as superglue, via reaction with formaldehyde.

- It is a precursor to synthetic caffeine via the intermediacy of theophylline. It is a building block for many drugs, including dextromethorphan, amiloride, sulfadimethoxine, and allopurinol, and also for Peldesine.
6. HAZARD CLASSIFICATION
Hazardous substance. (UN No. 3261)

Irritant

Corrosive

7. ANNUAL CAPACITY
5 MT.
8. STORAGE CONDITION
Store in closed container at ambient temperature. Avoid direct sun light.
9. PACKING DETAILS

20 kg net in HDPE container with two PE liners, strip sealed separately. 

10. SHELF LIFE
6 months.
Disclaimer
Typical properties should not be considered as specification.
Product covered by valid patents are not offered or supplied for commercial use. The Patent position should be verified by the customer.
Products will not be supplied to countries where they could be in conflict with existing patents.
Products currently covered by valid US patents are offered for R&D use in accordance with 35 USC 271 (e) (I) Above information is given in good faith and without warrenty.
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