European Inventory of Existing Commercial Chemical Substances (EINECS)
Listed
EC Inventory
Listed
United States Toxic Substances Control Act (TSCA) Inventory
Listed
China Catalog of Hazardous chemicals 2015
Not Listed
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC)
Listed
Korea Existing Chemicals List (KECL)
Listed
Canadian Domestic Substance List (DSL)
Listed
Canadian Non-Domestic Substance List (NDSL)
Not Listed
Japanese Existing and New Chemical Substances Inventory (ENCS)
Listed
4. SPECIFICATION
Physical Appearance
A White To Slightly Yellowish Crystalline Hygroscopic Cr
Freezing Point
64-68°C
Water Content (KF)
NMT 1.0%
Solubility
Clear Solution (5% In Water Is Clear)
Purity (HPLC)
NLT 96%
5. APPLICATION
- It is used as raw material to manufacture industrial organic chemicals.
- Cyanoacetic acid was used in the synthesis of N-piperidine-cyanacetamide and N-morpholyl-cyanacetamide. It was also used in the preparation of a panchromatic dye for dye-sensitized solar cells.
- Cyanoacetic acid can be used as a reagent:
Along with acetic anhydride for cyanoacetylation of various pyrroles, indoles, and aniline derivatives. It can also be used in other reactions such as cyclizations, syntheses of coumarins and other heterocycles.
To prepare of key intermediate via Knoevenagel condensation in the total synthesis of 5-acetamido-substituted melatonin derivatives as MT3 receptor ligands.
In the synthesis of aminopyrrolinone derivatives by reacting Ugi adducts of cyanoacetic acid and aromatic aldehydes.
- The largest scale reaction is its esterification to give the corresponding ester ethyl cyanoacetate, which is then transformed to ethyl cyanoacrylate used as superglue, via reaction with formaldehyde.
- It is a precursor to synthetic caffeine via the intermediacy of theophylline. It is a building block for many drugs, including dextromethorphan, amiloride, sulfadimethoxine, and allopurinol, and also for Peldesine.
6. HAZARD CLASSIFICATION
Hazardous substance. (UN No. 3261)
Irritant
Corrosive
7. ANNUAL CAPACITY
5 MT.
8. STORAGE CONDITION
Store in closed container at ambient temperature. Avoid direct sun light.
9. PACKING DETAILS
20 kg net in HDPE container with two PE liners, strip sealed separately.
10. SHELF LIFE
6 months.
Disclaimer
Typical properties should not be considered as specification.
Product covered by valid patents are not offered or supplied for commercial use. The Patent position should be verified by the customer.
Products will not be supplied to countries where they could be in conflict with existing patents.
Products currently covered by valid US patents are offered for R&D use in accordance with 35 USC 271 (e) (I) Above information is given in good faith and without warrenty.
A1. Cyanoacetic Acid is a white to slightly yellowish crystalline hygroscopic solid (HPLC purity not less than 96%, 64–68 °C range, water (KF) not more than 1.0%) used as a reagent for cyanoacetylation and Knoevenagel condensation, as the precursor of ethyl cyanoacetate and as a building block for dextromethorphan, amiloride and allopurinol.
Q2. What are the key specifications of Cyanoacetic Acid?
A2. A white to slightly yellowish crystalline hygroscopic solid; HPLC purity not less than 96%, 64–68 °C range, water (KF) not more than 1.0%. CAS 372-09-8.
Q3. How is Cyanoacetic Acid packed and how long is its shelf life?
A3. It is supplied in 20 kg HDPE containers with two strip-sealed PE liners. Shelf life is 6 months when stored in a closed container at ambient temperature, away from direct sunlight.
Q4. What is the annual capacity for Cyanoacetic Acid?
A4. Sarex Fine Chemicals manufactures Cyanoacetic Acid in India with an annual capacity of 5 MT.
