European Inventory of Existing Commercial Chemical Substances (EINECS)
Listed
EC Inventory
Listed
United States Toxic Substances Control Act (TSCA) Inventory
Not Listed
China Catalog of Hazardous chemicals 2015
Not Listed
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC)
Listed
Korea Existing Chemicals List (KECL)
Not Listed
Canadian Domestic Substance List (DSL)
Not Listed
Canadian Non-Domestic Substance List (NDSL)
Not Listed
Japanese Existing and New Chemical Substances Inventory (ENCS)
Listed
4. SPECIFICATION
Physical Appearance
Colorless to Yellow Solid or Viscous Liquid
Miscibility
Miscible with Methanol
Moisture Content (KF)
NMT 0.50%
Solubility
Freely Soluble in Dichloromethane
Assay (by Titration, Non Aqueous)
99.0 to 102.0 %
Identification By GC
Retention Time of the Sample should Match with the Standard
Total Impurities
NMT 1.0%
5-Ethyl-2-vinyl-pyridine
NMT 0.50%
5-Ethyl-2-methyl-pyridine (by GC)
NMT 0.20%
Purity By GC
NLT 99.0%
5. APPLICATION
- It is used as intermediates of Pioglitazone HCl.
- Pioglitazone is an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity.
- Pioglitazone is an antihyperglycaemic agent.
- Pioglitazone acts as an “insulin sensitizer”, providing a means to improve glycaemic control by reducing insulin resistance and thus decreasing hyperglycaemia in patients with type 2 diabetes mellitus.
6. HAZARD CLASSIFICATION
Non-Hazardous Substance.
Corrosive
Irritant
7. CAPACITY
72 MT.
8. STORAGE CONDITION
Store in closed container at ambient temperature. Avoid direct sunlight.
9. PACKING DETAILS
Outer Packing : 25 kg HDPE Open Mouth Drum
Inner Packing : Double H. M. Bag (White & Black)
150 Kg Net in GI drum
200 Kg Net in GI drum
10. SHELF LIFE
3 years.
Disclaimer
Typical properties should not be considered as specification.
Product covered by valid patents are not offered or supplied for commercial use. The Patent position should be verified by the customer.
Products will not be supplied to countries where they could be in conflict with existing patents.
Products currently covered by valid US patents are offered for R&D use in accordance with 35 USC 271 (e) (I) Above information is given in good faith and without warrenty.
Q1: What is 5-Ethyl pyridine-2-ethanol and what drug is it used to make?
A1: It is a pyridine-based heterocyclic alcohol (C9H13NO, mol. wt. 151) used as a key intermediate for manufacturing Pioglitazone HCl — an orally active thiazolidinedione antidiabetic drug that acts as an insulin sensitizer to reduce insulin resistance and hyperglycaemia in Type 2 diabetes patients.
Q2: What purity does this product meet and how is it tested?
A2: It meets a purity of NLT 99.0% by GC, with assay by non-aqueous titration at 99.0–102.0%, total impurities NMT 1.0%, and two specific impurities (5-Ethyl-2-vinyl-pyridine NMT 0.50% and 5-Ethyl-2-methyl-pyridine NMT 0.20%) controlled by GC.
Q3: What are the physical properties and hazard classification of this compound?
A3: It's a colorless to yellow solid or viscous liquid, freely soluble in dichloromethane and miscible with methanol. Although classified as non-hazardous overall, it carries both Corrosive and Irritant GHS hazard pictograms, requiring appropriate PPE during handling.
Q4: What is the shelf life and how should 5-Ethyl pyridine-2-ethanol be stored?
A4: It has a 3-year shelf life and should be stored in a closed container at ambient temperature away from direct sunlight. It's packed in 25 kg HDPE open mouth drums with double HM bags, or 150/200 kg GI drums.
Q5: Who manufactures and exports 5-Ethyl pyridine-2-ethanol in India?
A5: Sarex is a leading fine chemical manufacturer and exporter in India producing 5-Ethyl pyridine-2-ethanol at 72 MT annual capacity. As one of India's largest chemical exporters, Sarex supplies it to pharmaceutical companies in more than 40 countries, primarily the USA and Europe.
Corrosive
Irritant
