European Inventory of Existing Commercial Chemical Substances (EINECS)
Listed
EC Inventory
Listed
United States Toxic Substances Control Act (TSCA) Inventory
Listed
China Catalog of Hazardous chemicals 2015
Not Listed
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC)
Not Listed
Korea Existing Chemicals List (KECL)
Not Listed
Canadian Domestic Substance List (DSL)
Not Listed
Canadian Non-Domestic Substance List (NDSL)
Listed
Japanese Existing and New Chemical Substances Inventory (ENCS)
Listed
4. SPECIFICATION
Physical Appearance
White to off white crystaline powder
Melting Point
120 - 130°C
Moisture Content (KF) Use Pyridine as the Solvent
NMT 0.5%
Solubility
Soluble in methanol and sparingly soluble in water
Assay (by Titration, Acidimetry)
NLT 99%
Identification (HPLC)
Should comply the test
Single Unknown Impurity
NMT 0.1%
Total Impurities (HPLC)
NMT 0.50%
Purity by HPLC
NLT 99.5%
5. APPLICATION
It is used as intermediates of Pioglitazone HCl and Pioglitazone
HCl is Anit-Diabetic Drug.
6. HAZARD CLASSIFICATION
Non Hazardous material.
Irritant
7. ANNUAL CAPACITY
60 MT
8. STORAGE CONDITION
Store in closed container at ambient temperature. Avoid direct sunlight.
9. PACKING DETAILS
Outer Packing : 25 kg HDPE Open Mouth Drum
Inner Packing : Double H.M.Bag (White & Black)
10. SHELF LIFE
3 years.
Disclaimer
Typical properties should not be considered as specification.
Product covered by valid patents are not offered or supplied for commercial use. The Patent position should be verified by the customer.
Products will not be supplied to countries where they could be in conflict with existing patents.
Products currently covered by valid US patents are offered for R&D use in accordance with 35 USC 271 (e) (I) Above information is given in good faith and without warrenty.
Q1: What is 2,4-Thiazolidinedione and what is it used for in pharmaceuticals?
A1: It's a five-membered heterocyclic compound (C3H3NO2S, mol. wt. 117.13) used as a key intermediate for manufacturing Pioglitazone HCl, an anti-diabetic API belonging to the thiazolidinedione class. It appears as a white to off-white crystalline powder with a melting point of 120–130°C.
Q2: What purity standards does 2,4-Thiazolidinedione (P) meet?
A2: It meets a purity of NLT 99.5% by HPLC, assay NLT 99% by acidimetric titration, single unknown impurity NMT 0.1%, and total impurities NMT 0.50%, with moisture NMT 0.5% (using pyridine as solvent in KF testing).
Q3: What does the "(P)" designation in the product name indicate?
A3: The "(P)" likely denotes a specific pharmaceutical-grade quality designation, distinguishing it from lower-purity industrial grades, ensuring it meets the stringent impurity profile required for API intermediate use in drug manufacturing.
Q4: On which global chemical inventories is 2,4-Thiazolidinedione listed?
A4: It's listed on EINECS, EC Inventory, US TSCA, Canadian NDSL, and Japan ENCS. It is not listed on China IECSC, Korea KECL, or Canadian DSL — buyers supplying to those markets should verify compliance requirements.
Q5: Is Sarex a reliable manufacturer and exporter of 2,4-Thiazolidinedione for the pharma industry?
A5: Yes, Sarex manufactures 2,4-Thiazolidinedione (P) at 60 MT annual capacity in India and, as a leading fine chemical and API intermediate manufacturer and exporter, supplies it to pharmaceutical companies worldwide, with exports going primarily to the USA and Europe.
