European Inventory of Existing Commercial Chemical Substances (EINECS)
Listed
EC Inventory
Listed
United States Toxic Substances Control Act (TSCA) Inventory
Not Listed
China Catalog of Hazardous chemicals 2015
Not Listed
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC)
Not Listed
Korea Existing Chemicals List (KECL)
Not Listed
Canadian Domestic Substance List (DSL)
Not Listed
Canadian Non-Domestic Substance List (NDSL)
Not Listed
Japanese Existing and New Chemical Substances Inventory (ENCS)
Listed
4. SPECIFICATION
Physical Appearance
White to Off-white Powder
Impurity @ RRT 2.0
NMT 0.08%
Impurity @ RRT 1.9
NMT 0.08%
1-Phenylcyclopentaneacid Amide HPLC
NMT 3%
Melting Point
159-161°C
Moisture Content (KF)
NMT 0.5%
Solubility (2.5% in DMF)
Clear Solution
Total Unknown Impurities
NMT 2.0%
Single Impurity Major
NMT 1.0%
Assay (by Titration, Acidimetry)
98% - 101%
5. APPLICATION
- It is an intermediates of Pentoxyerine and It is use in Antitussive Drug. (to relieve coughing)
- It is an intermediate of Caramiphen. Caramiphen is a cholinergic antagonist used in Parkinson's disease.
- Additionally, it is used, in combination with phenylpropanolamine, as a cough suppressant and nasal decongestant for the symptomatic treatment of seasonal respiratory conditions.
-1-Phenyl-1-cyclopentanecarboxylic acid was used to prepare precursors required for solid phase synthesis of isoxazole and isoxazoline derivatives.
6. HAZARD CLASSIFICATION
Non Hazardous material.
Irritant
7. ANNUAL CAPACITY
24 MT
8. STORAGE CONDITION
Store in closed container at ambient temperature. Avoid direct sunlight.
9. PACKING DETAILS
STD Pack Size : 20 kg Net Wt. HDPE Drum
One Pallet Size : 18 Drums x 20kg Drums = 360 kg
Inner Packing : 2 plastic strip seal individually on each inner
10. SHELF LIFE
3 years.
Disclaimer
Typical properties should not be considered as specification.
Product covered by valid patents are not offered or supplied for commercial use. The Patent position should be verified by the customer.
Products will not be supplied to countries where they could be in conflict with existing patents.
Products currently covered by valid US patents are offered for R&D use in accordance with 35 USC 271 (e) (I) Above information is given in good faith and without warrenty.
Q1: What is 1-Phenyl-1-cyclopentanecarboxylic acid used for in pharmaceuticals?
A1: It's a pharmaceutical intermediate (C22H17N3O5 per the page; mol. wt. 190.24) used to manufacture Pentoxyerine (an antitussive/cough suppressant) and Caramiphen (a cholinergic antagonist used in Parkinson's disease). In combination with phenylpropanolamine, it's also used in symptomatic treatment of seasonal respiratory conditions.
Q2: What additional research applications does this compound support?
A2: It has been used to prepare precursors for solid-phase synthesis of isoxazole and isoxazoline derivatives, indicating its utility extends beyond finished drug API synthesis into medicinal chemistry research.
Q3: What purity and specification does this compound meet?
A3: It's a white to off-white powder with assay by acidimetric titration at 98–101%, melting point 159–161°C, moisture NMT 0.5%, and specific HPLC impurity controls — including 1-phenylcyclopentaneacid amide (NMT 3%), impurity at RRT 2.0 (NMT 0.08%), and impurity at RRT 1.9 (NMT 0.08%).
Q4: What is the annual production capacity and how is this compound packaged?
A4: Sarex manufactures it at 24 MT annually. Standard packing is 20 kg HDPE drums (18 drums per pallet = 360 kg), with two individually strip-sealed plastic liners inside each drum.
Q5: Is Sarex an established manufacturer and exporter of this pharma intermediate?
A5: Yes, Sarex is a leading fine chemical and pharmaceutical intermediate manufacturer in India, and as one of the country's largest chemical exporters, it supplies 1-Phenyl-1-cyclopentanecarboxylic acid to cough and Parkinson's drug producers across 40+ countries.
