European Inventory of Existing Commercial Chemical Substances (EINECS)
Not Listed
EC Inventory
Listed
United States Toxic Substances Control Act (TSCA) Inventory
Not Listed
China Catalog of Hazardous chemicals 2015
Not Listed
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC)
Not Listed
Korea Existing Chemicals List (KECL)
Not Listed
Canadian Domestic Substance List (DSL)
Not Listed
Canadian Non-Domestic Substance List (NDSL)
Not Listed
Japanese Existing and New Chemical Substances Inventory (ENCS)
Not Listed
4. SPECIFICATION
Physical Appearance
Light Yellow Solid
Identification (HPLC)
Identical
Purity (HPLC)
NLT 98%
Melting Point
116-117 °C
5. APPLICATION
1-Oxo-2,3-dihydro-1H-indene-4-carbonitrile is an organic chemical compound that is used as a reagent in the Friedel–Crafts acylation of chiral chlorides.
1-Oxo-2,3-dihydro-1H-indene-4-carbonitrile is key intermediate of Ozanimod. Ozanimod is a sphingosine 1-phosphate receptor modulator being studied to treat Multiple Sclerosis (MS) and inflammatory bowel disease (IBD) API- Ozanimod.
6. HAZARD CLASSIFICATION
Non Hazardous substance.
Irritant
7. ANNUAL CAPACITY
50 MT.
8. STORAGE CONDITION
Store at ambient temperature in dry place away from direct sun light.
9. PACKING DETAILS
25kg corrugated box pallet.
10. SHELF LIFE
3 years.
Disclaimer
Typical properties should not be considered as specification.
Product covered by valid patents are not offered or supplied for commercial use. The Patent position should be verified by the customer.
Products will not be supplied to countries where they could be in conflict with existing patents.
Products currently covered by valid US patents are offered for R&D use in accordance with 35 USC 271 (e) (I) Above information is given in good faith and without warrenty.
Q1: What is 1-Oxo-2,3-dihydro-1H-indene-4-carbonitrile and what drug does it lead to?
A1: Also known as 4-Cyano-1-indanone (C10H7NO, mol. wt. 157.17), it's a light yellow solid (purity NLT 98% by HPLC, melting point 116–117°C) that is a key intermediate for synthesizing Ozanimod — a sphingosine 1-phosphate (S1P) receptor modulator used to treat Multiple Sclerosis (MS) and inflammatory bowel disease (IBD).
Q2: What chemical reaction is this compound particularly useful for?
A2: It is used as a reagent in Friedel–Crafts acylation of chiral chlorides — a classic carbon-carbon bond-forming reaction in organic synthesis that is critical for building the bicyclic indanone core of complex pharmaceutical molecules like Ozanimod.
Q3: How limited is the regulatory inventory coverage for this compound?
A3: It's listed only on the EC Inventory (EC number 813-647-6). It is not currently on US TSCA, EINECS, China IECSC, KECL, Canadian DSL, NDSL, or Japan ENCS — buyers in regulated markets should assess compliance before sourcing.
Q4: What is the annual production capacity and packaging format?
A4: Sarex manufactures this at 50 MT annual capacity — significant for a specialty indanone intermediate — and packs it in 25 kg corrugated box pallets with a 3-year shelf life at ambient temperature.
Q5: Does Sarex manufacture and export this Ozanimod intermediate to global pharmaceutical companies?
A5: Yes, Sarex is a leading fine chemical manufacturer and pharmaceutical intermediate producer in India, and as one of the country's largest chemical exporters, it supplies this MS drug intermediate to API manufacturers in more than 40 countries.
